After ?2–six?h there is a precipitous increase in cTn reflecting intensive myocardial necrosis and degradation of myofibrillar cTn (red line). With the evolution of assay know-how, the 99th percentile value of cTn which serves for a Reduce-off value for the prognosis of AMI has become accordingly minimized. Edited from Hochholzer et al.This take